Albumin as a drug delivery and diagnostic tool and its market approved products.
نویسندگان
چکیده
Albumin is one of the most extensively studied endogenous proteins which are used in the fabrication of drug delivery and diagnostic technologies during last 10 years. This review provides a summary of products involving the use of albumin as a drug delivery tool for getting better the pharmacokinetics of a drug by developing the targetted drug delivery systems and diagnosing the pathologies. Using albumin, following market approved products have been developed: Levemir and Victoza (antidiabetic product), Abraxane (antimetastatic breast cancer product), and Nanocoll and Albures (for lymphoscintigraphy and diagnosis of cancer and rheumatoid arthritis).
منابع مشابه
Nanocomposite Based on Albumin Protein and Review of Its Applications in Medical Engineering
Albumin is a protein macromolecule that it has been attractive since the early 20th century and has several therapeutic applications. Albumin is an aboundant serum with good biocompatibility, hematopoiesis and biodegradability in blood. The existence of multiple functional groups makes it possible to carry significant amounts of therapeutic and diagnostic factors, as well as targeting factors. ...
متن کاملHow Do Palladium Complexes Affect on Coil Structure of Human Serum Albumin in the Presence of Carbon Nanotube? A Molecular Dynamics Study
To investigate the interaction and adsorption of drug and carbon nanotube on human serum albumin, three anti-cancer drugs ([Pd(phen)(R-gly)]NO3, R = methyl, propyl and amyl) with different hydrophobic tails and anticancer activities were selected. These drugs have better anti-tumor activity and less side effects than that known cis-platinum drug. Human serum albumin is also ...
متن کاملA comprehensive study of HSA interaction with TMP using molecular docking and molecular dynamics methods: as an appropriate tool for drug delivery systems
Background: Human serum albumin (HSA) is one of the most prominent protein in human blood. Trimethoprim (TMP) is an efficient antibiotic drug for treatment of pneumocystis pneumonia (PCP). Patients with HIV/AIDS and cancer are extremely affected by the disease due to immune system deficiency. Objective: The aim of this study is to evaluate the molecular dynamics simulation (MD) of HSA with TMP...
متن کاملBiological properties, therapeutic and diagnostic applications of Samarium and Samarium nanoparticles
Lanthanides are a family of elements, commonly known as rare earth elements. Metal samarium as one of the most important member of this family, which plays very important roles in the diagnosis and treatment of various diseases, especially cancer. Several lanthanide complexes, samarium in particular, have shown anticancer effects on tumor cells. This paper is tried to review the biological prop...
متن کاملکاربرد نانوذرات در دارورسانی پوستی وکاربردهای موضعی
Diseases of the skin can cause harm and emotional distress in patients. The desirable drug is one with least complications and most effectiveness. By prolongation of target exposure, drug effectiveness could be improved. There are several suggested solutions, including the use of chemical enhancers, electroporation, iontophoresis, and the use of nanoparticles as carriers of pharmaceutical age...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta poloniae pharmaceutica
دوره 70 4 شماره
صفحات -
تاریخ انتشار 2013